RBX1 (ring-box 1)

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Role of the Arabidopsis RING-H2 protein RBX1 in RUB modification and SCF function.

The ubiquitin-related protein RUB/Nedd8 is conjugated to members of the cullin family of proteins in plants, animals, and fungi. In Arabidopsis, the RUB conjugation pathway consists of a heterodimeric E1 (AXR1-ECR1) and a RUB-E2 called RCE1. The cullin CUL1 is a subunit in SCF-type ubiquitin protein ligases (E3s), including the SCF(TIR1) complex, which is required for response to the plant horm...

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The Complexity of Black-Box Ring Problems

We study the complexity of some computational problems on finite black-box rings whose elements are encoded as strings of a given length and the ring operations are performed by a black-box oracle. We give a polynomial-time quantum algorithm to compute a basis representation for a given black-box ring. Using this result we obtain polynomial-time quantum algorithms for several natural computatio...

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Lower Bounds on Black-Box Ring Extraction

The black-box ring extraction problem is the problem of extracting a secret ring element from a black-box by performing only the ring operations and testing for equality of elements. An efficient algorithm for the black-box ring extraction problem implies the equivalence of the discrete logarithm and the Diffie-Hellman problem. At the same time this implies the inexistence of secure ring-homomo...

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Selective Recruitment of an E2∼Ubiquitin Complex by an E3 Ubiquitin Ligase*

RING E3 ligases are proteins that must selectively recruit an E2-conjugating enzyme and facilitate ubiquitin transfer to a substrate. It is not clear how a RING E3 ligase differentiates a naked E2 enzyme from the E2∼ubiquitin-conjugated form or how this is altered upon ubiquitin transfer. RING-box protein 1 (Rbx1/ROC1) is a key protein found in the Skp1/Cullin-1/F-box (SCF) E3 ubiquitin ligase ...

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The Role of RING Box Protein 1 in Mouse Oocyte Meiotic Maturation

RING box protein-1 (RBX1) is an essential component of Skp1-cullin-F-box protein (SCF) E3 ubiquitin ligase and participates in diverse cellular processes by targeting various substrates for degradation. However, the physiological function of RBX1 in mouse oocyte maturation remains unknown. Here, we examined the expression, localization and function of RBX1 during mouse oocyte meiotic maturation...

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ژورنال

عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology

سال: 2011

ISSN: 1768-3262

DOI: 10.4267/2042/44491